| 胃腺癌组织EGFR基因表达及其临床意义的研究 |
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| 引用本文： | 赵亚娟,刘海芳,朱献斐,黄震.胃腺癌组织EGFR基因表达及其临床意义的研究[J].中华肿瘤防治杂志,2010,17(4). |
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| 作者姓名： | 赵亚娟 刘海芳 朱献斐 黄震 |
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| 作者单位： | 义乌市中心医院病理科,浙江,义乌,322000 |
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| 基金项目： | 浙江省义乌市科研计划项目(08-3-07) |
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| 摘 要： | 目的:探讨胃腺癌EGFR基因表达及其与临床病理参数和术后5年生存率的关系。方法:显色原位杂交(CISH)检测55例胃腺癌组织EGFR基因表达。结果:55例胃腺癌组织EGFR基因扩增7例(阳性率12.7%);EGFR基因扩增患者5年生存率为14.3%,明显低于EGFR基因正常患者5年生存率(31.3%),χ2=11.935,P=0.001;阳性病例组织学类型均为肠型(Lauren分型);低分化(χ2=4.814,P=0.041)、浸及浆膜外(χ2=4.816,P=0.028)、临床分期为Ⅲ+Ⅳ期(χ2=4.786,P=0.029)以及有淋巴结转移(χ2=4.38,P=0.042)的胃腺癌EGFR基因扩增率明显增高。结论:EGFR基因扩增的胃腺癌分化程度低、易发生浆膜外浸润和淋巴结转移,临床分期为Ⅲ+Ⅳ期,术后5年生存率低。
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| 关 键 词： | 胃肿瘤/病理学 腺癌/病理学 基因 EGFR 原位杂交 |
Expression of EGFR and Its clinic significance in gastric adenocarcinoma tissues |
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| ZHAO Ya-juan,LIU Hai-fang,ZHU Xian-fei,HUANG Zhen.Expression of EGFR and Its clinic significance in gastric adenocarcinoma tissues[J].Chinese Journal of Cancer Prevention and Treatment,2010,17(4). |
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| Authors: | ZHAO Ya-juan LIU Hai-fang ZHU Xian-fei HUANG Zhen |
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| Institution: | ZHAO+Ya-juan,LIU+Hai-fang,ZHU+Xian-fei,HUANG+Zhen+Department+of+Pathology,Center+Hospital+of+Yiwu,Yiwu+322000,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the expression of EGFR in gastric adenocarcinoma tissues,its clinical-pathological parameter and 5-year survival rate after operation.METHODS:The expression of EGFR gene in gastric adenocarcinoma(n=55)was detected by chromogenic in situ hybridization(CISH).RESULTS:The amplification of EGFR gene was 12.7%,namely 7 cases of gastric adenocarcinoma.EGFR amplification was merely present in the intestinal type of gastric adenocarcinomas(according to Lauren's classification).The 5-year sur... |
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| Keywords: | stomach neoplasms/pathology adenocarcinoma/pathology genes EGFR in situ hybridization |
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