软骨修复材料在运动性膝关节软骨损伤修复中的作用膝关节

背景：评价软骨修复材料在膝关节软骨损伤修复中的效果,为医务、科研工作者的研究提供一定的借鉴。方法：采用电子检索的方式,在万方数据库（http：//www.wanfangdata.com.cn/）中检索2000-01/2011-03关于修复材料在膝关节软骨损伤研究的文章,关键词为＂生物材料;关节软骨;缺损;修复＂。排除重复研究、普通综述或Meta分析类文章,筛选纳入26篇文献进行评价。结果：膝关节软骨损伤在运动性损伤中较为常见,现在主要的治疗方法是自体骨软骨移植修复膝关节软骨缺损。新型的软骨替代材料研究仍处于动物试验阶段,且在动物体内长期疗效及远期的生物力学变化还未有进一步的证实,进入临床试验更需要一个过程。结论：关节软骨损伤修复的基础研究与临床治疗,虽仍存在许多重点和难点问题亟待探索,但关节软骨损伤修复正从生物材料移植向人工再造活性软骨的崭新阶段迈进。随着各种新型材料的研制和开发,关节软骨损伤修复研究将日益完善,并为临床奠定坚实的基础,应用前景十分广阔。

Cartilage repair materials used for repair of sports-induced knee cartilage injuries

BACKGROUND：To evaluate the effect of cartilage repair materials on the repair of knee cartilage injuries so as to support a certain experience for medical and scientific research workers.METHODS：An electronic search of Wanfang database was performed using the keywords of ＂biomaterials;articular cartilage;injuries;repair＂ to retrieve articles about repair materials for knee cartilage injuries published between 2000-01 and 2011-03.Repetitive articles,review and Meta analysis were excluded,and finally 26 articles were eligible.RESULTS：Knee cartilage injuries are commonly seen in sports-induced injuries.The main treatment is to repair cartilage defects in the knee with autogenous bone graft.The new cartilage substitute material is still in the phase of animal tests.The long-term efficacy and biomechanical changes in model animals need further studies,and then the related clinical trials can be done.CONCLUSION：There are many important and difficult problems to be explored in the basic and clinical research concerning the repair of knee cartilage injuries.However,a new progress from biomaterial grafts to reconstructed active bone is realized in the repair of knee cartilage injuries.With the development and research of various new-type materials,the repair of knee cartilage injuries can be increasingly perfect.