Gabor4,波变换和希尔伯特变换研究海马区癫痫发作间期尖波对theta振荡能量特性的影响

背景：Theta振荡是海马区神经活动具有代表性的特征，也是从更为微观领域研究癫痫与认知关系的重要切入点。目的：分析海马区癫痫发作间期尖波对Theta振荡能量特性的影响。方法：采用法国马赛地中海大学医学院提供的8只致痫大鼠和10例患者脑电数据，同时采集相应致痫大鼠在注射致痫药物无发作间期尖波出现时的脑电数据作对照。利用Gabor小波变换和希尔伯特变换分别提取Theta振荡在尖波作用前、后的能量，并将这两种方法提取Theta振荡能量的结果进行比较。结果与结论：癫痫组Theta能量动态特性：癫痫发作间期尖波削弱了Theta振荡能量，而在经历癫痫发作间期后的较长时间，Theta振荡能量得到恢复。推测脑默认网络的连接强度受到癫痫状态的影响，存在变弱的可能。而默认网络的减弱，盛认知对l能下降的一种病殚基础。

Effect of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1： A Gabor wavelet and Hilbert transform study

BACKGROUND： Theta oscillation is a representative characteristic of neural activity in hippocampus and serves as the starting point for the study of epilepsy and cognition in micro-ways. OBJECTIVE： To investigate the effects of the interictal spike and waves of epileptic seizure on theta oscillation in hippocampal CA1. METHODS： The iEEG data of 8 epileptic rats and 10 patients from School of Medicine, Mediterranean University, Marseilles, France were collected, and their corresponding iEEG data without spike and waves as controls. Gabor wavelet and Hilbert transform were used for extraction of the power of theta oscillation before and after the spike waves. The outcomes of Gabor wavelet and Hilbert transform were compared. RESULTS AND CONCLUSION： Dynamic characteristics of theta power in epilepsy group： Epileptic interictal spike and waves weaken the theta oscillation power, but after a long period of spike and waves, theta oscillation power recovered. It is speculated that the brain＇s default network connection strength is affected by status epilepticus and may be weakened. However, the weakening of the default network is a pathological basis of cognitive decline.