成纤维细胞生长因子与器官发育

背景：成纤维细胞生长因子能够影响多种器官组织的形态发生、分化及功能,对多种器官的发育具有决定性作用。目的：综述近年来关于成纤维细胞生长因子在器官发育中所起的作用,为进一步研究器官发育提供理论基础。方法：检索Pubmed（1995/2010）和CNKI（2001/2010）数据库,检索关键词分别为＂fibroblast growth factor,tooth development,kidney development,lung development,salivary gland development＂,＂成纤维细胞生长因子、牙齿发育、肾脏发育、肺发育、涎腺发育＂。纳入与成纤维细胞生长因子结构、功能及其与器官发育相关的研究,同一领域研究则选择近期发表及发表在权威杂志的文章。结果与结论：共收集文献850篇,排除发表时间较早及重复研究文献,共纳入37篇英文文献和2篇中文文献。目前研究发现,牙齿、肺、肾脏、羽毛、毛发、心脏、涎腺的发育都是从上皮与间充质相互作用开始的。成纤维细胞生长因子能够促进上皮和间充质细胞之间的相互作用,诱导两种细胞的增殖并抑制其凋亡,成纤维细胞生长因子与器官发育紧密相关。

Fibroblast growth factors and organogenesis

BACKGROUND：Fibroblast growth factor（FGF） has many effects on differentiation,proliferation,apoptosis and other functions during development of different organs.OBJECTIVE：To review the functions of FGF during development of different organs,and to provide theoretical basis for further study.METHODS：Articles were retrieved from PubMed and CNKI database with the key words of ＂FGF,tooth development,kid and ney development,lung development,salivary gland development＂ both in English and Chinese from the year of 1995 to 2010 2001 to 2010 respectively.Studies concerning the structure,function of FGF and relative organogenesis were included.Literatures about the same circle published in the near future or on the authoritative journals were included.RESULTS AND CONCLUSION：A total of 850 documents were collected,and 37 English articles and 2 Chinese papers were summarized.The initial development of tooth,lung,kidney,feather,hair follicle,cardiovascular and salivary gland arises from the interaction between the epithelial and mesenchymal cells.FGF plays important roles on enhancement of interaction,induction of cell proliferation and differentiation,inhibition of cell death,etc,during organogenesis.