细菌纤维素减轻兔耳增生性瘢痕的作用

背景：国内外已有研究报道细菌纤维素对皮肤创伤愈合具有促进作用,但是其对增生性瘢痕是否有治疗作用尚不清楚。目的：观察细菌纤维素对兔耳增生性瘢痕的疗效。方法：建立兔耳腹侧增生性瘢痕模型,术后第21天创面上皮化后,对每只兔耳5个不同瘢痕面随机给予5种不同处理方式：持水性分别为1：5,1：6,1：8细菌纤维素组、阳性对照组（贴敷瘢痕贴）、阴性对照组（未贴任何敷料且瘢痕自然生长）。观察不同处理后第0,14,21,28,42,56天瘢痕面大体形态学及组织学变化。结果与结论：持水性1：5,1：6,1：8细菌纤维素组瘢痕增生厚度低于阴性对照组,但高于阳性对照组（P〈0.01）。与阴性对照组比较,持水性1：5,1：6,1：8细菌纤维素组瘢痕组织中真皮层薄,成纤维细胞少,胶原纤维较细、排列较整齐;与阳性对照组组比较,持水性1：5,1：6,1：8细菌纤维素组成纤维细胞数稍多,胶原也稍粗、排列也稍不整齐。3种细菌纤维素组间瘢痕厚度及成纤维细胞数量为1：5细菌纤维素组〉1：6细菌纤维素组〉1：8细菌纤维素组（P〈0.05）。说明细菌纤维素有效抑制了兔耳创面愈合后增生性瘢痕的形成,并且持水性越高,效果越好。

Effects of bacterial cellulose on reducing hypertrophic scar in rabbit ears

BACKGROUND：Bacterial cellulose（BC） as a kind of new biological materials for the wound healing before scarring has been reported in the world,but the efficacy of bacterial cellulose used in hypertrophic scar after wound healing remains unclear.OBJECTIVE：To investigate the effects of BC on reducing rabbit ear hypertrophic scar.METHODS：Hypertrophic scar model were established in rabbit ears.At 21 days postoperative wound epithelization was observed,five different scars of each rabbit ear which were given different treatments were randomly divided into five groups：patching absorbent film（water holding capacity：1：5,1：6,1：8） as the BC treated groups,patching silicone scar film as a positive control group,without sticking any litter and natural growth of scar as a negative control group.At 0,14,21,28,42,56 days of givening scar surface different treatments,the development process of hypertrophic scar was observed grossly and histologically RESULTS AND CONCLUSION：The scars tissue hyperplasia thickness of the BC treated groups was lower than that of negative control group,but higher than that of positive control group（P 0.01）.Compared with the negative control group,the dermal thickness in scars was thinner,number of fibroblasts was fewer,collagen fibers in scars were losser and more regular in the BC treated groups;compared with the positive control group,number of fibroblasts was slightly increased,collagen fibers in scars were slightly denser and irregular in the BC treated groups.The number of fibroblasts and the scars tissue thickness in the BC treated-group were compared,the BC（1：5） treated-group the BC（1：6） treated-group the BC（1：8） treated-group（P 0.05）.It has been proved that BC effectively inhibits the rabbit ear hyperplastic scar after the wound healing.and the more water content the BC has,the better effect it appears in hypertrophic scar.