干细胞在心脏再生医学中的作用及中医药研究策略

背景：中医对心脏再生有其独特认识,但中医药介入干细胞与心脏再生医学还处于初步探索阶段。目的：分析和总结干细胞与心脏再生相关的研究进展,对中医药如何介入心脏再生研究进行初步探讨。方法：以关键词＂stem cell＂与＂cardiac regenerative medicine＂检索PubMed数据库、关键词＂干细胞＂与＂中医＂检索CNKI中国期刊全文数据库2000/2010的相关文献,语言种类不限,对符合标准的文献证据进行综合提炼分析。保留其中44篇进行归纳总结。结果与结论：分析表明干细胞应用于心脏再生医学的研究已广泛拓展,包括胚胎干细胞、骨髓干细胞、成体心脏干细胞等均显示了再生心肌的能力及其应用前景。中医对心脏再生的认识蕴含在阴阳观、五行母子规律及精气学说中。中医药要介入心脏再生医学,就需要对中医理论在心脏再生医学中的认识进行系统整理,深入挖掘中医复方,重视中药有效组分靶向干细胞及加强对有效方药作用机制的研究。

Effect of stem cells and strategy of traditional Chinese medicine in cardiac regenerative medicine

BACKGROUND： Traditional Chinese medicine （TCM） has its unique understanding on cardiac regeneration,but there is preliminary exploration stage of stem cells and cardiac regenerative medicine intervention in TCM.OBJECTIVE： To analyze and summarize correlative research development of stem cells and cardiac regeneration,and preliminarily discuss how to intervene cardiac regeneration in TCM.METHODS： PubMed database was searched with the Keywords ＂stem cell,cardiac regenerative medicine＂ and China National Knowledge Infrastructure with the key words ＂stem cell,TCM＂ for literatures published between 2000 and 2010,no limitation in language.We analyzed and summarized the literatures evidence that met criterions.Finally,43 articles were included.RESULTS AND CONCLUSION： The analysis demonstrated that the study of use of stem cells in cardiac regenerative medicine has been expanded widely,including embryonic stem cells,bone marrow stem cells,adult cardiac stem cells,et al,which indicate the ability to regenerate myocardium and application perspectives.The understanding on cardiac regeneration in TCM is contained in yin and yang concept,the law of mother and son in five elements and vital essence theory.TCM needs to collate the understanding of cardiac regenerative medicine in TCM theory systematically,TCM compounds,value active components of TCM targeting to stem cells and to enhance researches on mechanisms of effective TCM.