骨质疏松动物模型的研究现状

背景：骨质疏松的发病机制十分复杂,但又不能直接在人体上进行实验,需要复制类似人类骨质疏松的动物模型进行研究。目的：全面分析各种骨质疏松动物模型的造模方法及优缺点,为今后研究骨质疏松症,在模型选择上提供参考。方法：电子检索中国知识资源总库（CNKI）系列数据库和ESBCO Medline数据库1990-01/2010-07收录的骨质疏松模型的相关综述和论文报告。中文检索词为＂骨质疏松,动物模型＂;英文检索词为＂osteoporosis,animalmodels＂。共检索到469篇相关文献,对文章进行初审,纳入文献主题内容与此文联系紧密;原创、论点论据可靠的试验文章;观点明确,分析全面的文章。排除内容陈旧或重复文献及试验设计中不是采用随机对照试验的文章。结果与结论：共纳入符合标准的38篇文献。目前用于骨质疏松症研究的动物模型主要有诱发性动物模型和转基因动物模型。各种骨质疏松动物模型可能只侧重于表现该疾病的某种病因、某一阶段、某些主要症状及某些病理生理变化,必须根据研究目的,选择合适的造模方法和实验动物。

Research status of animal models of osteoporosis

BACKGROUND：The pathogenesis of osteoporosis is very complicated.But test can not be done directly in humans.Animal models of human-like osteoporosis are needed for detailed study.OBJECTIVE：Comprehensively analyze the advantages and disadvantages of various modeling methods and animals of osteoporosis,so as to provide a reference of choicing the models for future research of osteoporosis.METHODS：Searched CNKI series database and ESBCO Medline database for the relevant review and papers of osteoporosis models published from January 1990 to July 2010 with the key words of ＂osteoporosis,animal models＂ in Chinese and English.469 documents were retrieved.Each article was checked.Inclusive criterion：the documents were closely with the subject;the article was original and the viewpoint was reliable;the viewpoint was clear and analysis was comprehensive.Old,duplicate documents and experiments without randomized controlled trials were excluded.RESULTS AND CONCLUSION：Totally 38 articles were adopted in this article.The induced animal models and transgenic animal models are mainly used in the research of osteoporosis.Various animal models of osteoporosis may only focus on the certain causes,certain stage,some of the main symptoms and some pathophysiological changes of disease.Accordingly,appropriate modeling methods and experimental animals should be selected based on research objective.