钛及钛合金表面生物活性改性及效果评价

背景：钛及钛合金是常用的医用生物材料,其具有良好的生物相容性,但其缺乏骨诱导的能力,其与骨组织之间只是一种机械性的接触。目的：概述钛及其合金表面生物活性改性的方法及对于改性后效果评价的方法,为临床应用提供参考。方法：应用计算机检索PubMed数据库,CNKI数据库中关于钛及钛合金表面生物活性改性的文章,英文检索词为＂titanium,titanium alloy,coating,bioactivity,bone＂,限定文献语言种类为＂English＂,中文检索词为＂钛,钛合金,涂层,活性改性,骨组织＂,限定文献语言种类为中文。结果与结论：在表面生物活性改性的方法中,主要有等离子体喷涂法、微弧氧化法、溶胶-凝胶法及生物仿生法等。钛及钛合金表面的活性涂层已经从单一涂层发展到复合涂层、梯度涂层、纳米梯度涂层,同时多种改性技术的联合运用,也让钛及其合金表面的涂层性能更加完善。对于改性后的效果研究,主要以模拟体液浸泡、成骨细胞培养,亲骨荧光素染色及放射影像学观察为主。对钛及钛合金进行表面生物活性改性是个复杂的工程,既要考虑改性后涂层骨诱导的能力,同时也需要兼顾涂层与基体结合强度的问题。只有对涂层组层进一步研究并利用多种技术对钛及钛合金表面进行处理,才能使其表面的涂层活性更高,并且结合牢固。

Methods and efficacy of surface bioactivity modification for titanium and titanium alloy

BACKGROUND：Titanium and titanium alloy are commonly used for medical biological materials,they have good biocompatibility,but lack of the ability of bone induction,the contact between titanium and bone tissue is a mechanical contact.OBJECTIVE：To review the methods and efficacy of surface bioactivity modification for titanium and titanium alloy,and to provide references for further clinical application.METHODS：A computer-based online search of literatures related to methods of surface bioactivity modification for titanium and titanium alloy was performed in PubMed database and CNKI database using the Key words of＂titanium,titanium alloy,coating,bioactivity,bone＂ in English and in Chinese respectively.RESULTS AND CONCLUSION：The surface modification methods include plasma spraying,micro-arc oxidation,sol-gel and biomimetic methods.The surface coating of titanium and titanium alloy has been developed from a single coating to the composite coatings,gradient coatings and nano-gradient coatings.The joint use of two or three modification methods enhances the properties of the coating.After the surface modifications,the efficacy is investigated by simulating body fluid soaking,the culture of the osteoblasts,bone affinity fluorescein staining and radiology detection.Surface bioactivity modification for titanium and titanium alloy is a complex engineering,which requires to consider the bioactivity of surface coating and its bonding strength between the substrate,as well as the ability of bone induction.With the development of surface modification technology,the bioactivity and binding of surface coating for titanium and titanium alloy will be enhanced.