银屑病与白血病染色体畸变及脆性位点的研究进展

银屑病是遗传和环境等多种因素相互作用的多基因遗传性疾病,其遗传度估计值为60%~80%,但确切机制尚不清楚。有关药物(如乙双吗啉等)使银屑病患者继发白血病增多,其中以早幼粒细胞性白血病(M3)多见。有学者认为是药物诱发染色体畸变导致白血病,但也有部分学者认为银屑病患者本身存在易患白血病的倾向。本文就银屑病与白血病之间的关系做简要综述。

Studies on the Chromosomal Aberration and Fragile Site of Psoriasis and Leukemia: a Review of Recent Literatures

Psoriasis is a chronic inflammatory disease, The etiology is involved in many factors including genetic predisposition and environmental impact. The heritability degree of psoriasis is estimated between 60% and 80%. Many investigators pay attention to the genetic predisposition and epidemiologic feature and begin to study the correlation between chromosome aberration or gene mutation and pathogenesis. More and more clinical case reports and laboratory studies about psoriasis associated with acute myelogenous leukemia have been reported. Most of the patients with psoriasis and leukemia are the subtype of AML-M3. Someone consider the psoriasis with leukemia is caused by bimolane. On the other hand, the others consider there are some genetic defects existed in the patients with psoriasis, including chromosome instability and defect of DNA repair. Here is the review about the relationship between psoriasis and leukemia.