| HMG-CoA还原酶抑制剂的合成(下) |
| |
| 引用本文： | 蔡正艳,宁奇,周伟澄. HMG-CoA还原酶抑制剂的合成(下)[J]. 中国医药工业杂志, 2004, 35(11): 687-691 |
| |
| 作者姓名： | 蔡正艳 宁奇 周伟澄 |
| |
| 作者单位： | 上海医药工业研究院,上海,200437 |
| |
| 摘 要： | 2芳杂环与侧链的缩合反应 2.1卤代甲基芳香化合物与含醛基6碳侧链的缩合Wittig反应或Wittig-Hornor反应是合成HMG-CoA还原酶抑制剂类药物的常用方法.
|
| 关 键 词： | HMG-CoA还原酶抑制剂 药物 Wittig反应 合成 侧链 缩合 常用方法 甲基 芳香化合物 |
| 文章编号： | 1001-8255(2004)11-0687-05 |
Synthesis of Hypolipidemic HMG-CoA Reductase Inhibitors |
| |
| CAI Zheng-Yan,NING Qi,ZHOU Wei-Cheng. Synthesis of Hypolipidemic HMG-CoA Reductase Inhibitors[J]. , 2004, 35(11): 687-691 |
| |
| Authors: | CAI Zheng-Yan NING Qi ZHOU Wei-Cheng |
| |
| Affiliation: | Shanghai Institute of Pharmaceutical IndustryShanghai 200437 |
| |
| Abstract: | Several synthetic methods for hypolipidemic HMG-CoA reductase inhibitors were reviewed, including thepreparation of the side chains with the suitable groups such as aldehydo, acetylenyl, sulfonyl, phosphono or amino as well as thecondensation of these chains with the heteroaromatic compounds by Wittig-Hornor or Julia-Kocienski Olefination reaction. |
| |
| Keywords: | HMG-CoA reductase inhibitor synthesis review |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
