测肝硬化患者血清CA125和总胆汁酸水平的临床意义

目的：探讨肝硬化患者血清CA125与总胆汁酸水平变化及其临床意义。方法：选择79例肝硬化患者作为实验组，根据Child-Pugh肝功能分级积分法分级；22例健康体检人员作为对照组。检测两组血清CA125与总胆汁酸水平，分析两者与肝功能分级的关系。结果：肝硬化患者血清CA125及总胆汁酸水平与对照组比较，差异有高度统计学意义（P＜0.01），两者水平随肝功能损害程度的加重呈进行性升高。结论：血清CA125与总胆汁酸呈正相关，联合检测血清CA125、总胆汁酸水平能较早地反映肝脏合成及其代谢功能，对疾病的治疗和预后有重要的临床价值。

Clinical significance of determination of serum CA125 and TBA in patients with cirrhosis

Objective： To investigate the clinical significance of serum CAl25 and TBA in patients with cirrhosis. Methods： 79 cases of patients with cirrhosis were selected as experimental group and divided according to Child-Pugh hepatic function classification. 22 healthy people were selected as normal controls. Serum CA125 and TBA were measured by automatic biochemistry analyzer. The alteration of CA125 and TBA with hepatic functional classification was investigated. Results： The levels of serum CA125 and TBA of experimental group were markedly higher than those of control group （P〈 0.01）. The levels of serum CA125 and TBA rose gradually with the degree of hepatic functional lesion. Conclusion： Serum CA125 and TBA are positively correlated, they can reflect hepatic synthesis metabolism, evaluate clinical value of treatment and prognosis in patients with cirrhosis.