| 系统性红斑狼疮患者T淋巴细胞亚群Fas及bcl-2抗原的表达 |
| |
| 引用本文： | 蒋莉,赵丽娟,何春涤. 系统性红斑狼疮患者T淋巴细胞亚群Fas及bcl-2抗原的表达[J]. 中华皮肤科杂志, 1998, 31(1): 4-5 |
| |
| 作者姓名： | 蒋莉 赵丽娟 何春涤 |
| |
| 作者单位： | 中国医科大学第一临床学院普通内科(蒋莉!110001沈阳，赵丽娟!110001沈阳)，中国医科大学第一临床学院皮肤科(何春涤!110001沈阳) |
| |
| 摘 要： | 目的 通过对 SL E患者末梢血 CD4 、CD8 、CD45 RO T淋巴细胞亚群表面 F as及 bcl-2抗原表达的测定 ,寻找与 SL E发病有关的因素。方法 用流式细胞仪双色解析法。结果 与健康对照组比较 ,SL E患者的 CD4 、CD8 、CD45 RO T淋巴细胞亚群表面 Fas抗原表达明显增强 (P<0 .0 1) ,而 bcl-2抗原表达明显降低 (P<0 .0 1)。结论 末梢血 CD4 、CD8 、CD45 RO T淋巴细胞亚群表面 F as抗原表达增强 ,bcl-2抗原表达降低即过度细胞凋亡现象可能与 SL E发病有关。
|
| 关 键 词： | 红斑狼疮 系统性 T淋巴细胞亚群 Fas bcl-2 |
Expression of F as and bcl-2 Antigens on T L ym phocyte Subsets in Patients with System ic L upus Erythe- m atosus |
| |
| Jiang L i,Zhao L ijuan,H e Chundi.Dep artment of General Internal Med icine,The F irst Clini- cal College,China Medical University,Shenyang. Expression of F as and bcl-2 Antigens on T L ym phocyte Subsets in Patients with System ic L upus Erythe- m atosus[J]. Chinese Journal of Dermatology, 1998, 31(1): 4-5 |
| |
| Authors: | Jiang L i Zhao L ijuan H e Chundi.Dep artment of General Internal Med icine The F irst Clini- cal College China Medical University Shenyang |
| |
| Affiliation: | Jiang L i,Zhao L ijuan,H e Chundi.Dep artment of General Internal Med icine,The F irst Clini- cal College,China Medical University,Shenyang 110 0 0 1 |
| |
| Abstract: | Objective To study the expression of F as and bcl-2 antigens on T lym phocyte subsets in patients with SL E and healthy controls.Methods F low cytometry(two colour analysis) were used. Results We observed thatthe expression of Fas antigen on CD4 ,CD8 ,CD45 RO T lym phocyte subsets of SL E patients was significantly higher than that of healthy controls(P<0 .0 1) and thatthe expression of bcl-2 antigen was significantly decreased(P<0 .0 1) .Conclusion Increased expression of F as antigen and decreased expression of bcl-2 antigen on T lymphocyte subsets m ay be related to the pathogenesis of SL E. |
| |
| Keywords: | L upus erythem atosus systemic T lym phocyte subset Fas bcl-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
