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多指标正交法优选盐制补骨脂饮片的炮制工艺
引用本文:殷放宙,李林,李伟东,陆兔林,蔡宝昌. 多指标正交法优选盐制补骨脂饮片的炮制工艺[J]. 中国中药杂志, 2013, 38(3): 346-349
作者姓名:殷放宙  李林  李伟东  陆兔林  蔡宝昌
作者单位:南京中医药大学药学院,江苏南京,210046
基金项目:国家自然科学基金项目(30701108);江苏高校优势学科建设工程项目PAPD(ysxk-2010);南京中医药大学中药学一级学科开放课题项目(2011ZYX2-008)
摘    要:目的:采用正交试验法优选盐制补骨脂工艺.方法:以其所含的香豆素、黄酮、酚类等12个成分为考察指标,采用L9(34)正交试验比较不同因素对盐制补骨脂的影响.结果:确定的最佳工艺为100 g补骨脂加2 g盐,闷润2h,150℃炒制10 min.结论:正交试验的结果合理、可靠,为盐制补骨脂的炮制工艺提供了依据.

关 键 词:补骨脂  盐制  正交试验
收稿时间:2012-08-30

Optimization of preparation of salt-processed Psoraleae Fructus medicines with multi-index orthogonal method
YIN Fang-zhou,LI Lin,LI Wei-dong,LU Tu-lin and CAI Bao-chang. Optimization of preparation of salt-processed Psoraleae Fructus medicines with multi-index orthogonal method[J]. China Journal of Chinese Materia Medica, 2013, 38(3): 346-349
Authors:YIN Fang-zhou  LI Lin  LI Wei-dong  LU Tu-lin  CAI Bao-chang
Affiliation:College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China;College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210046, China
Abstract:Objective: To optimize the preparation of salt-processed Psoraleae Fructus by the orthogonal test method. Method: With the 12 components such as coumarin, flavone and phenolics as study indexes, a L9 (34) orthogonal test was adopted to compare the effect of different factors on salt-processed Psoraleae Fructus. Result: According to the finalized optimal process, 100 g Psoraleae Fructus was added with 2 g salt, moistened for 2 hours, and then fried for 10 min at 150°. Conclusion: The orthogonal test is so reasonable and reliable that it can provide basis for the preparation of salt-processed Psoraleae Fructus.
Keywords:Psoraleae Fructus  salt-processed preparation  orthogonal test
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