Resveratrol, a Red Wine Constituent Polyphenol, Protects Gastric Tissue Against the Oxidative Stress in Cholestatic Rats |
| |
| Authors: | Vedat Kirimlioglu MD Cengiz Ara MD Mehmet Yilmaz MD Dincer Ozgor MD Burak Isik MD Gokhan Sogutlu MD Hale Kirimlioglu MD Aysun Bay Karabulut PhD Sezai Yilmaz MD Cuneyt Kayaalp MD Saim Yologlu MD |
| |
| Affiliation: | (1) Departments of General Surgery, Inonu University School of Medicine, Malatya, Turkey;(2) Departments of Pathology, Inonu University School of Medicine, Malatya, Turkey;(3) Departments of Biochemistry, Inonu University School of Medicine, Malatya, Turkey;(4) Departments of Biostatistics, Inonu University School of Medicine, Malatya, Turkey;(5) Department of General Surgery, Inonu University Turgut Ozal Medical Center, 44069 Malatya, Turkey |
| |
| Abstract: | This experimental study was designed to determine the effects of resveratrol on the level of malondialdehyde (MDA), reduced glutathione (GSH), and nitric oxide (NO) in gastric tissue after bile duct ligation (BDL). Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, BDL (BDL only group; n = 7); and Group 3, BDL plus resveratrol (n = 7). Animals in the resveratrol group were treated with 10 mg/kg resveratrol (i.p.) once a day throughout 28 days. In the resveratrol group, levels of MDA and NO in gastric tissue were significantly lower than in the BDL-only group (P < 0.001). The level of GSH in the resveratrol group was significantly higher than in the BDL-only group (P < 0.001). The present study demonstrates that intraperitoneal administration of resveratrol maintains antioxidant defenses and reduces oxidative gastric damage. This effect of resveratrol may be useful to preserve gastric tissue under oxidative stress due to cholestasis. |
| |
| Keywords: | resveratrol biliary cirrhosis malondialdehyde reduced glutathione nitric oxide |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
