Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice. |
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| Authors: | A Tabatabaei T L Perry S Hansen C Krieger |
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| Affiliation: | Department of Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada. |
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| Abstract: | The protective effect of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest that NMDA receptors may be involved in some of the neurotoxicity produced by MPTP. |
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