| 计算机辅助设计抗感染中药复方的实验研究 |
| |
| 引用本文： | 缪珠雷,李玉虎,包寅,徐栋梁,张辉,王易.计算机辅助设计抗感染中药复方的实验研究[J].中草药,2009,40(10):1602-1607. |
| |
| 作者姓名： | 缪珠雷 李玉虎 包寅 徐栋梁 张辉 王易 |
| |
| 作者单位： | 上海中医药大学,上海,201203 |
| |
| 基金项目： | 上海市教委科研项目，上海市教委莺点学科巾西医结合基础项目 |
| |
| 摘 要： | 目的 验证利用基于人工免疫智能系统的计算机辅助设计抗感染中药新复方的可行性.方法 选取<伤寒论>中所载之经方作为中药复方训练样本,金黄色葡萄球菌腹腔感染实验动物模型ig给予各中药复方,取含药血清观察其抑菌效果,按抑菌力大小给以相应编码;将这些复方中各味中药的药性特征进行编码,输入一个神经网络,用人工免疫系统实现各神经元之间的连接权值优化,使之具备实现中药复方药性特征和抑菌力之间非线性映射的能力,提取出抗金黄色葡萄球菌感染的中药复方的组方规律;然后由计算机随机生成复方,由系统根据预测的抑菌能力取排名靠前者输出得到计算机设计的抗感染中药复方,进行动物实验验证.结果经过验证,计算机所设计的复方可以有效提高小鼠含药血清抗金黄色葡萄球菌的能力.结论初步证明,计算机可以用于辅助设计抗感染中药新复方.
|
| 关 键 词： | 中药复方 人工免疫系统 金黄色葡萄球菌 抗感染 |
| 修稿时间： | 2009/1/28 0:00:00 |
Experimental study on assistant designing of computer for new Chinese herbal compounds with anti-infectious function |
| |
| MIAO Zhu-lei,LI Yu-hu,BAO Yin,XU Dong-liang,ZHANG Hui and WANG Yi.Experimental study on assistant designing of computer for new Chinese herbal compounds with anti-infectious function[J].Chinese Traditional and Herbal Drugs,2009,40(10):1602-1607. |
| |
| Authors: | MIAO Zhu-lei LI Yu-hu BAO Yin XU Dong-liang ZHANG Hui and WANG Yi |
| |
| Institution: | Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China |
| |
| Abstract: | study the feasibilit y of artificial immune system (AIS) in assistant designing of computer for new Chinese herbal compo unds with anti infectio us function. Methods Agroup of Chinese herbal drug compounds from Treatise on Exogenous Febrile and Miscell aneous Diseases were selected as training samples. |
| |
| Keywords: | Chinese herbal co mpo und artificial immune system (A IS) S t a p hy lococcus aureus Ro sen2bach anti2infection |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《中草药》浏览原始摘要信息 |
| 点击此处可从《中草药》下载免费的PDF全文 |
|
