| 中药创新药物研究开发的回顾、策略与实践 |
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| 引用本文： | 杨义芳,杨必成,金丽丽.中药创新药物研究开发的回顾、策略与实践[J].中草药,2009,40(10):1513-1519. |
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| 作者姓名： | 杨义芳 杨必成 金丽丽 |
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| 作者单位： | 上海医药工业研究院中药研究室,上海,200240 |
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| 摘 要： | 以"十一五"、"十五"重大科技专项为主线,回顾中药创新药物研究的历程,通过剖析美国FDA第一个植物药VeregenTM对中药研发的启示,以及对创新药物研究中的重大成果学习、感悟,试图提出创新中药研发策略并指出实践的路径.以中药复方创制新药为中药创新的主要途径,创新可以从新物质,包括新化合物和新有效部位/群或组分配伍,一个已知化合物或已知提取物等的新药用及名优中成药的二次开发3方面实现;并借鉴国际经验以近代临床应用为基础的靶点依赖性先导物的筛选、评价与优化和在分子及基因水平对中药复方的作用机制和分子靶点进行诠释,来支撑具有中国特色的原创治疗药的研究与开发.
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| 关 键 词： | 中药创新药物 研究开发 策略 |
Retrospection,stratagem,and practice on innovative drug research and development of Chinese materia medica |
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| YANG Yi-fang,YANG Bi-cheng and JIN Li-li.Retrospection,stratagem,and practice on innovative drug research and development of Chinese materia medica[J].Chinese Traditional and Herbal Drugs,2009,40(10):1513-1519. |
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| Authors: | YANG Yi-fang YANG Bi-cheng and JIN Li-li |
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| Institution: | Department of Chinese Materia Medica, Shanghai Institute of Pharmaceutical Industry, Shanghai 200240, China;Department of Chinese Materia Medica, Shanghai Institute of Pharmaceutical Industry, Shanghai 200240, China;Department of Chinese Materia Medica, Shanghai Institute of Pharmaceutical Industry, Shanghai 200240, China |
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| Abstract: | Taking the national key scient ific and technological project Plan as its main clue,the innovative Chinese mat eria medica ( CMM ) resear ch cour se has been reviewed in t his paper. Based on the enlightenment from the firsther bal medicine Ver egen TM,which has been approved by FDA,together wit h the study and comprehension of many great achievements of new drug research,the strategy of innovative CMM research and development. |
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| Keywords: | innovative Chinese mat eria medica research and development stratagem |
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