度洛西汀与帕罗西汀治疗广泛性焦虑对照研究

目的:探讨度洛西汀与帕罗西汀治疗广泛性焦虑症的疗效及安全性。方法:将80例广泛性焦虑症患者随机分为度洛西汀组(40例)和帕罗西汀组(40例)治疗。疗程6周。采用汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)评定疗效,用不良反应量表(TESS)评定不良反应。结果:度洛西汀组40例患者中有39例完成研究,帕罗西汀组40例中38例完成研究。治疗结束时,度洛西汀组痊愈率为56.4%,有效率为89.7%;帕罗西汀组分别为52.6%和86.8%。两组差异无统计学意义(P>0.05)。两组HAMA,SAS评分在治疗后均下降;度洛西汀组第1周末总分低于帕罗西汀组,余时点组间比较差异无显著性(P>0.05)。两组均未发生严重不良事件。结论:度洛西汀对广泛性焦虑患者的总体疗效与帕罗西汀相当,但起效更快。

Comparative study of Duloxetine and Paroxetine in the treatment of generalized anxiety disorder

Objective:To compare the efficacy and safety of Duloxetine and Paroxetine in the treatment of generalized anxiety disorder.Methods:80 patients with generalized anxiety disorder were randomly divided to Duloxetine group(n=40) and Paroxetine group(n=40).and the duration of treatment was 6 weeks.The curative effects was assessed with the Hamilton rating scale for anxiety(HAMA) and Self-Rating Anxiety Scale(SAS),untoward reaction were assessed with treatment emergent symptom scale(TESS).Results: 39 of the 40 subjects in the Duloxetine group and 38 of the 40 subjects in the Paroxetine group completed the 6 weeks of treatment.At the end of treatment,the recovery rate and effective rate in Duloxetine group were 56.4% and 89.7%,and those in Paroxetine group were 52.6% and 86.8%,there was no significant difference(P>0.05).Both the HAMA scores and SAS scores in the two groups lowered obviously compared with before treatment(P<0.01).At the end of the first week the mean total HAMA score in the Duloxetine group was significantly lower than in the Paroxetine group,but there was no significant difference at the other points(P>0.05).No severe adverse events occurred in both groups.Conclusions: The medication Duloxetine has the similarly efficacy with the medication of Paroxetine,but has earlier efficacy.