| 乙酰螺旋霉素口腔贴片的研制及体外释药的考察 |
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| 引用本文： | 王军.乙酰螺旋霉素口腔贴片的研制及体外释药的考察[J].中国药师,2006,9(11):1024-1025. |
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| 作者姓名： | 王军 |
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| 作者单位： | 武汉大学人民医院药学部,武汉,430060 |
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| 摘 要： | 目的:研制乙酰螺旋霉素口腔贴片。方法:以卡波姆934P和HPMC(K4M)作为黏附材料,制备口腔贴片,并对其生物黏附力及体外释放度进行了考察,采用一阶导数光谱法测定乙酰螺旋霉素的含量。结果:卡波姆934P的生物黏附性优于HPMC,体外释放均符合Higuchi方程,HPMC的缓释效果优于卡波姆934P。结论:处方中以卡波姆934P与HPMC配比为1:1时为最优处方。
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| 关 键 词： | 乙酰螺旋霉素 口腔贴片 生物黏附力 体外释药 |
| 文章编号： | 1008-049X（2006）11-1024-02 |
| 收稿时间： | 2006-01-13 |
| 修稿时间： | 2006年1月13日 |
Study on Bioadhesion and Release of Acetylspiramycin Buccal Adhesive Tablets in vitro |
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| Wang Jun.Study on Bioadhesion and Release of Acetylspiramycin Buccal Adhesive Tablets in vitro[J].China Pharmacist,2006,9(11):1024-1025. |
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| Authors: | Wang Jun |
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| Abstract: | Objective:To study the preparation of acetylspiramycin buccal adhesive tablets. Method:Carbopol 934P and HPMC (K4M) were used as adhesive materials to prepare the buccal tablets. The bioadhesive force and release of the buccal tablets were detected in vitro. Derivative absorption spectrophotometry was employed to determine the concentration of acetylspiramycin. Result:The bioadhesive force of Carbopol 934P was better than that of HPMC while the sustained release effect of HPMC was better than that of Carbopol 934P. The release of all the buccal tablets was accordant with Higuchi equation in vitro. Conclusion: The best formulation was composed of Carbopol 934P and HPMC with ratio of 1:1. |
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| Keywords: | Acetylspiramycin Buccal tablets Bioadhesive force Release in vitro |
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