Chronic hyperprolactinemia and plasma lipids in women |
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Authors: | H M Heshmati G Turpin J L de Gennes |
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Institution: | (1) Department of Endocrinology and Metabolism, Hôpital de la Pitié, Paris, France |
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Abstract: | Summary Plasma total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and low-density lipoprotein-cholesterol (LDL-C) were studied in 15 hyperprolactinemic women who had a prolactin (PRL) adenoma, in comparison to 15 age-matched control women. In the hyperprolactinemic group, plasma lipids were also correlated to age, excess body weight (EBW), plasma PRL, and estradiol-17 (E2). Plasma TC, TG, and LDL-C were similar in both hyperprolactinemic and control women, while plasma HDL-C was significantly lower (P<0.01) in the hyperprolactinemic group. The correlation study showed a significant negative correlation between HDL-C and EBW (r=–0.64;P<0.02) and a slightly significant positive correlation between TG and PRL (r=0.54;P<0.05). The direct effect of PRL on plasma lipids is difficult to establish since many factors influencing lipid metabolism are altered during hyperprolactinemia.Abbreviations EBW
excess body weight
- E2
estradiol-17
- GH
growth hormone
- HDL-C
high-density lipoprotein-cholesterol
- LDL-C
low-density lipoprotein-cholesterol
- LPL
lipoprotein lipase
- PRL
prolactin
- RIA
radioimmunoassay
- TC
total cholesterol
- TG
triglycerides |
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Keywords: | Chronic hyperprolactinemia Plasma lipids |
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