Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion |
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| Authors: | J E Wellington D N Love J M Whalley |
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| Institution: | (1) School of Biological Sciences, Macquarie University, Sydney;(2) Department of Veterinary Pathology, University of Sydney, New South Wales, Australia |
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| Abstract: | Summary Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a complement-dependent neutralising antibody (7B10) which recognised the large subunit of EHV-1 gB. This indicated that EHV-1 gB, in common with gB homologues of herpes simplex virus and other herpesviruses, plays a role in the cell-cell fusion process. |
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