A Pedigree Analysis of a Family With Familial Hypercholesterolemia |
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Authors: | Li Jianjun Wang Yaolin Hu Chenglin Chen Jiangbin Wang Jingming Xu Jiaoli |
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Affiliation: | Li Jianjun,Wang Yaolin,Hu Chenglin,Chen Jiangbin Wang Jingming,Xu JiaoliDepartment of Cardiology,The first Affiliated Hospital,Hubei Medical University,Wuhan 430060,PR China |
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Abstract: | Objective The current study was designed to investigate the features of a family with familial hypercholesterolemia(FH). Methods Twenty members of three generations in a family with FH were enrolled in the study. The data collected were from clinical observation and subjected to pedigree analysis. Results The proband was a 41 years old male who suffered from angina pectoris with multi-vessel stenosis of coronary artery at the age of 40. Among 20 members, 8 individuals were demonstrated with hypercholes-terolemia in this family with the total incidence of 40% [54.5% (6/11) in male and 22. 2% (2/9) in femaleThe serum total cholesterol level was elevated in childhood from 7. 1 to 10. 8 mmol/L and tended to be raised with increasing age. In addition, the level of total cholesterol was found to be elevated both in a monozy-gote twin brothers and their offspring in the family. Conclusion FH appears to be a hereditary disease of autosomal dominance inheritance and the outcome of FH patients with coronary heart disease seems to be poor in prognosis. |
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Keywords: | Familial hypercholesterolemia Coronary heart disease Pedigree analysis |
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