| Abstract: | In a study of the effect of lipoproteins of atherogenic classes on proliferative activity of peripheral lymphocytes in patients (n = 44) with ischemic heart disease (IHD) and healthy subjects (n = 16), VLDL isolated from hyperlipidemia blood were shown to have a more suppressive effect on proliferation of PHA-induced lymphocytes than those from healthy subjects. Effect analysis of VLDL isolated from patients with different hyperlipidemia types revealed that VLDL obtained from high triglyceride plasma depressed proliferation 85-75%, while VLDL withdrawn from high cholesterol plasma 45-55% (p less than 0.05). With addition of modified (oxidized) VLDL to PHA-activated lymphocytes oxidized VLDL were demonstrated to have a greater inhibitory effect as compared with intact VLDL. The observed peculiarities of the VLDL effect in hyperlipidemia may underlie the reduced functional activity of lymphocytes, discovered in IHD patients (n = 81). |
