| 血清可溶性CD40配体和胎盘生长因子水平与冠状动脉粥样硬化病变的相关性 |
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| 引用本文： | 黄斌,匡希斌,雷长城.血清可溶性CD40配体和胎盘生长因子水平与冠状动脉粥样硬化病变的相关性[J].中国心血管病研究杂志,2008,6(8):599-601. |
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| 作者姓名： | 黄斌 匡希斌 雷长城 |
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| 作者单位： | 南华大学附属第二医院心内科; |
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| 摘 要： | 目的研究血清可溶性CIMO配体（sCD40L）和胎盘生长因子（PIGF）与冠状动脉粥样硬化病变的相关性。方法静脉采血检测健康对照组（30名）及冠心病组（60例）血清sCD40L及PIGF水平，并将冠心病组上述指标血清水平与该组患者冠脉造影病变支数及Gensini冠脉病变积分进行相关性分析。结果与对照组比较，冠心病组血清sCD40L与PIGF水平明显升高（16．72±3．16）ng／L和（6．35±1．16）ng／L。（42．35±4．16）pg／ml和（15．8±2．73）pg／ml，P〈0．05]；血清sCD40L（r1=0．62，r2=0．67，r3=0．75，P〈0．05）与PIGF（r1=0．42，r2=0．53，r3=0．58，P〈0．05）水平与冠脉病变支数均呈正相关。结论血清sCIMOL与PIGF水平在冠心病患者中升高，可作为评估冠脉病变严重程度的指标。
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| 关 键 词： | CD40配体 胎盘生长因子 动脉粥样硬化 |
Relation of plasma level of sCD40L and PIGF with coronary atherosclerotic lesion |
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| HUANG Bin,KUANG Xi-bin,LEI Chang-cheng.Relation of plasma level of sCD40L and PIGF with coronary atherosclerotic lesion[J].Chinese Journal of Cardiovascular Review,2008,6(8):599-601. |
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| Authors: | HUANG Bin KUANG Xi-bin LEI Chang-cheng |
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| Institution: | HUANG Bin,KUANG Xi-bin,LEI Chang-cheng.Department of Cardiovascular Internal Medical,the No.2 Hos-pital Affliated to Nanhua University,Hengyang,421001) |
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| Abstract: | Objective To study the plasma level of soluble CD40 ligand(sCD40L) and placental growth factor(PIGF) in patients with coronary artery disease and the normal group,and the correlation between two indexes above and coronary lesion severity.Methods The plasma levels of sCD40L and PIGF were measured by an enzyme linked immunosorbent assay(ELISA) in 60 patients with coronary heart disease and 30 normal controls,then we assessed the lesion severity of coronary artery with Gensini coronary scoring system and analy... |
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| Keywords: | CD40 ligand Placental growth factor Atherosclerosis |
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