舒必利合用西酞普兰治疗阻滞性抑郁症的临床研究

目的:观察舒必利治疗阻滞性抑郁症的疗效和不良反应。方法:对62例阻滞性抑郁症患者,随机分为合用组(舒必利合并西酞普兰,31例患者)和单用组(单用西酞普兰,31例患者),治疗8周,采用汉密顿抑郁量表(HAMD)和副反应量表(TESS)评定不良反应。结果:治疗第4、6、8周末两组患者间HAMD总分和阻滞症状项目评分比较,合用组患者低于单用组,差异有统计学意义(P<0.01或P<0.05);治疗8周末合用组和单用组患者的显效率分别为83.87%和58.06%,差异有统计学意义(P<0.01);两组患者间TESS评分比较,单用组患者主要以恶心、呕吐等胃肠道反应为主,而合用组患者则无明显不良反应发生,两组患者比较差异显著。结论:小剂量舒必利合并西酞普兰治疗阻滞性抑郁症疗效较单用西酞普兰好,且起效快,舒必利可消除西酞普兰所致的恶心、呕吐等胃肠道不良反应。

Clinical study on sulpiride combined with citalopram in treatment of retardative depression

Objective：To observe effects and adverse reactions of sulpiridein treatment of retardative depression. Methods：62 patients with retardative depression were randomly divided into study group（ sulpiride combined with citalopram,31 cases） and control group（ citalopram, 31 cases） . All the patients were treated for 8 weeks. The adverse reactions were evaluated with Hamilton depression scale （HAMD） and treatment emergent symptom scale （TESS）. Results：At the end of 4th, 6th, and 8th week of the treatment, the total score of HAMD and item score of retardative symptom in study group were lower than those of control group, and there werestatisti-cal differences （P〈0. 01 or P〈0. 05）. At the end of 8th week of the treatment, the effective rates of study group and control group were 83. 87% and 58. 06%, respectively, and there was the statistical difference （P〈0. 01）. For TESS score, the cases in control group had gastrointestinal adverse reactions, such as nausea and vomiting;while no adverse reactions were observed instudy group, and there was the significant difference. Conclusions：The effect of low dosage of sulpiride combined with citalopram is better than citalo-pram alone in the treatment of retardative depression, and it takes effect faster as well. Sulpiride can eliminate nausea, vomiting and other gastrointestinal adverse reactions induced by citalopram.