HPV、TCT检查联合阴道镜下活检用于宫颈癌筛查的临床价值

目的探讨人乳头状瘤病毒）HPV）检测、膜式液基薄层细胞学检查（TCT）联合阴道镜下活检在宫颈癌筛查中的临床意义。方法选取2010年5月-2013年4月在该院门诊就诊的3102例有性生活史并自愿进行宫颈癌筛查的患者，分别进行HPV、TCT检测和阴道镜下活检。对病理检查结果阳性的476例患者，比较HPV和TCT检测对宫颈癌前病变及宫颈癌的检出符合率。结果HPV检测检出符合率为92．2％（439／476），TCT检出符合率为89．3％（425／476），两种方法检出符合率比较差异无统计学意义（P〉0．05）；HPV、TCT检查联合阴道镜下活检的检出符合率为100．0％。结论HPV、TCT检查联合阴道镜下活检有助于提高宫颈癌的检出率，早期发现癌前病变，降低病死率。

Analysis on the Clinical Value of HPV,TCT Combined with Biopsy under Colposcopy for the Screening of Cervical Cancer

Objective To investigate the clinical value of human papilloma virus（HPV）,membrane thinprep cytologic test （TCT） combined with biopsy under colposcopy for the screening of cervical cancer.Methods 3102 cases of patients visited in the outpatient of our hospital from May,2010 to April,2013 were selected;and all the patients had the history of sexual life and were willing to undergo cervical cancer screening.HPV,TCT and biopsy under colposcopy was performed in the patients respectively. For 476 cases with positive pathological examination resuhs,the detection coincidence rates of HPV and TCT for cervical precancerous lesions and cervical cancer were compared.Results The detection coincidence rate of HPV was 92.2%（439/476）, and that of TCT was 89.3%（425/476）,the difference was not statistically significant（P 〉 0.05）.The detection coincidence rate of HPV,TCT combined with biopsy under colposcopy was 100%.Conclusion HPV,TCT testing combined with biopsy under colposcopy can significantly improve the detection rate of cervical cancer, early detect precancerous lesions and reduce the mortality.