成人非酒精性脂肪性肝病的临床特点和危险因素分析

目的探讨成人非酒精性脂肪性肝病（NAFLD）的临床特点和危险因素。方法220例体检中发现的NAFLD病例和218例非脂肪性肝病体检者均在体检过程中接受行为因素调查，并进行回顾性对照分析，采用多元Logistic回归分析方法研究NAFLD的独立危险因素。结果NAFLD组ALT、AST和γ-GT血清水平显著高于对照组（P〈0．01），NAFLD组肥胖、2型糖尿病、心脑血管疾病、高脂血症等发病率显著高于对照组（P〈0．05），Wi、BMI、HOMA、TG、缺乏锻炼、CHOL、高脂饮食与NAFLD密切相关（P〈0．01或P〈0．05）。结论NAFLD并非良性病变，肥胖、IR、高脂血症、缺乏运动与高脂饮食在NAFLD发病中具有重要意义，健康管理是一项值得期待的防治NAFLD的措施。

Clinial features and risk factors of nonalcoholic fatty liver disease in adults

Objective To investigate the clinical features and risk factors assocaited with nonalcoholic fatty liver disease （NAFLD） in adults. Methods There 220 NAFLD patients and 218 non fatty liver adults were examined and were survey. The risk factors associated with NAFLD were analyzed by using Logistic regression analysis. Results The levels of serum ALT, serum AST and serum γ-GT in NAFLD group were significantly marked higher than those in the control group （P 〈 0.01 ）. The incidences of obesity, type 2 diabetes mellitus, heart and cerebral blood vessel disease and hyperlipidemia in NAFLD group were significantly higher than those in the control group （P 〈 0.05）. The factors of WI, BMI, HOMA, serum TG, lack of exercise, serum CHOL and high lipid food were closely associated with NAFLD （P 〈 0.01 or P 〈 0.05）. Conclusion NAFLD is not a benign lesion. Obesity, IR, hyperlipidemia, lack of exercise and high lipid food are statistically significant risk factors for NAFLD. Health management may be a measure for prevention and treatment of NAFLD.