| MMP-9在突出腰椎间盘中的表达及意义 |
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| 引用本文： | 王兆丰,武宇赤,雒萌. MMP-9在突出腰椎间盘中的表达及意义[J]. 疾病监测与控制, 2009, 0(4): 195-197 |
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| 作者姓名： | 王兆丰 武宇赤 雒萌 |
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| 作者单位： | 内蒙古医学院第三附属医院骨科,内蒙古包头014010 |
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| 摘 要： | 目的检测突出组和正常组腰椎间盘中基质金属蛋白酶9（matrix metalloproteinase-9，MMP-9）表达，探讨MMP-9在突出腰椎间盘中的作用及意义。方法通过免疫组化方法，应用MMP-9多克隆抗体，对40例突出腰椎间盘和20例正常腰椎间盘标本进行染色。结果突出组的MMP-9阳性细胞率显著高于正常组，非包含组的MMP-9阳性细胞率显著高于包含组。结论MMP-9在突出组腰椎间盘中高表达，提示MMP-9可能与椎间盘退变有关。
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| 关 键 词： | 腰椎间盘突出症 基质金属蛋白酶9 免疫组化 |
The Expression And Significance Of Matrix Metalloproteinase-9 In Herniated Lumbar Intervertebral Disc |
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| WANG Zhao-feng,WU Yu-chi,LUO Meng. The Expression And Significance Of Matrix Metalloproteinase-9 In Herniated Lumbar Intervertebral Disc[J]. , 2009, 0(4): 195-197 |
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| Authors: | WANG Zhao-feng WU Yu-chi LUO Meng |
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| Affiliation: | (The third Affiliated Hospital of Inner Mongolia Medical College, baotou 014010, China) |
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| Abstract: | Objective To detect expression of matrix metalloproteinase-9 in the herniated groups and the normal group,dicuss effection and significance of matrix metalloproteinase-9 in herniated lumbar intervertebral disc.Methods The expression of MMP-9 was tested by immunohistochemistry method, forty specimens of herniated intervertebral disc tissue and twenty normal disc tissue were immunostained with anti human MMP-9 polyclonal antibody.Result The positive cell rate of matrix metalloproteinase-9 in the herniated group was significantly higher than in the normal group, The positive cell rate of matrix metalloproteinase-9 in the uncontained group was significantly higher than in the contained group.Conclusion MMP-9 was high expression in herniated lumbar intervertebral disc,which showed that MMP-9 was related to intervertebral disc degeneration. |
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| Keywords: | herniated lumbar intervertebral disc： MMP-9： immunohistochemistry |
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