258例抗结核药物所致不良反应分析

目的分析结核病专科医院住院患者抗结核药物所致不良反应发生情况及对化疗的影响。方法对我院2006年5月-2008年5月住院的结核病患者病历中由专业医师提供病例记录、医嘱单、实验室及相关辅助检查结果，回顾性分析抗结核药物所致不良反应的发生情况及对化疗的影响。结果603例住院患者中发生不良反应258例，占42．8％（258／603）。最多见的不良反应为胃肠反应，占所有不良反应的43．4％（112／258）。因不良反应严重调整化疗方案46例，占17．8％（46／258）。其中肝功能异常占14．3％（37／258）。结论抗结核联合治疗方案中不良反应发生率相对较高，应重视抗结核药物所致的不良反应，加强对相关人员的培训和对患者的教育，密切监测及时发现，正确处理各种不良反应。肝损害是影响结核病治疗工作的主要不良反应，应予以重视。

Adverse Reactions Of Anti-Tuberculosis Drug-Induced In 258 Cases

Objective The purpose Analyze the tuberculosis specialist hospital patients anti-TB drugs due to adverse events and chemotherapy. Methods Retrospectively analyze the anti-TB drugs due to the occurrence of adverse events and Of chemotherapy tuberculosis patients in the medical records during May 2006 -May 2008 from doctors to provide records of cases, a single doctor＇s advice, and laboratory test results. Results 603 cases of adverse reactions occurred in patients in 258 cases, accounting for 42.8% （258/603）. The most common adverse reactions are gastrointestinal reactions which take up 43.7% of all （112/258）o Adjusted chemotherapy 46 cases as a result of serious adverse reactions, accounting for 17.8% （46/258）. Abnormal liver function which accounted for 14.3% （37/258）. Conclusion Discussion Joint anti-TB treatment in the incidence of adverse reactions is relatively high, should pay attention to anti-tuberculosis drug-induced side effects, and strengthen personnel training and education of patients, close monitoring to detect and correctly handle a variety of adverse reactions. Liver damage is the main TB treatment side effects, must be given.