Effect of Predominant Methanogenic Flora on Outcome of Lactose Hydrogen Breath Test in Controls and Irritable Bowel Syndrome Patients of North India |
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Authors: | S V Rana S K Sinha S Sharma H Kaur D K Bhasin and K Singh |
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Institution: | (1) Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India;(2) House #137, Sector 15-A, Chandigarh, 160015, India |
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Abstract: | The relationship between methanogenic flora and hydrogen (H2) production is considered to be a possible confounding factor in the interpretation of hydrogen breath tests (H2BT). Therefore, the present study was conducted prospectively and included 154 IBS patients (fulfilling Rome II criteria)
and 286 age-and-sex-matched apparently healthy controls. Each subject underwent H2BT after overnight fasting using 25 g lactose. Methane and H2 were measured using an SC Microlyser from Quintron, USA, at baseline and every 30 min for a total of 4 h. Subjects with fasting
methane concentration <10 ppm were labeled as low methane producers (LMP) and >10 ppm as predominant methane producers (PMP).
A rise >20 ppm over base line in hydrogen concentration was taken as +ve hydrogen breath test. IBS and control groups included
66.78% and 67.53% males, respectively. Mean age in the two groups were 48.52 ± 30.54 years (range 15–68 years) and 45.67 ± 30.54 years
(range 15–78 years), respectively. Hydrogen breath test was +ve in 77/154 (50%) IBS patients and in 142/286 (49.65%) in controls
(P > 0.05). It was also observed that the hydrogen breath test was −ve due to PMP in 5/77 (6.49%) of IBS patients and in 29/154
(20.14%) in controls. PMP affected lactose hydrogen breath tests in 6.49–20.14% subjects. This effect is more apparent in
apparently healthy subjects as compared to patients with IBS. |
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Keywords: | Lactose hydrogen breath test Methane Irritable bowel syndrome |
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