| 奥硝唑中空栓的制备及质量控制 |
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| 引用本文： | 李金伟,董根山,李俊岭,曹玮.奥硝唑中空栓的制备及质量控制[J].中国药房,2006,17(13):987-988. |
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| 作者姓名： | 李金伟 董根山 李俊岭 曹玮 |
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| 作者单位： | 1. 河南省人民医院,郑州市,450003
2. 河南中医学院,郑州市,450003 |
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| 摘 要： | 目的:制备奥硝唑中空栓并建立其质量控制方法。方法:以半合成脂肪酸甘油酯为基质制成中空栓;采用紫外分光光度法测定主药奥硝唑含量,测定波长为316nm。结果:奥硝唑检测浓度在6.0~18.0μg/ml范围内线性关系良好(r=0.9 997),平均回收率为99.80%(RSD=0.75%,n=5)。结论:本方法简便、准确、重现性好,可用于奥硝唑中空栓的质量控制。
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| 关 键 词： | 奥硝唑 中空栓 紫外分光光度法 质量控制 |
| 文章编号： | 1001-0408(2006)13-0987-02 |
| 收稿时间： | 11 8 2005 12:00AM |
| 修稿时间： | 01 10 2006 12:00AM |
Preparation and Quality Control of Ornidazole Hollow Suppository |
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| LI Jinwei,DONG Genshan,LI Junling,CAO Wei.Preparation and Quality Control of Ornidazole Hollow Suppository[J].China Pharmacy,2006,17(13):987-988. |
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| Authors: | LI Jinwei DONG Genshan LI Junling CAO Wei |
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| Abstract: | OBJECTIVE:To prepare ornidazole hollow suppository and to establish its quality control.METHODS:The compound metronidazole hollow suppository was prepared with semisynthesis fatty acid glyceride as ground sudstance.The content of ornidazole was determined by ultraviolet spectrophotometry at a detection wavelength of316nm.RESULTS:The linear concentration range of ornidazole was6.0～18.0μg/ml(r=0.9997)and the average recovery was99.80%(RSD=0.75%, n=5).CONCLUSIONS:This method is simple,accurate and reproducible,and suitable for the quality control of ornidazole hollow suppository. |
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| Keywords: | Ornidazole Hollow suppository Ultraviolet spectrophotometry Quality control |
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