利用摄碘率高峰时间推测Graves’甲亢患者有效半减期

目的探讨吸碘率峰值与有效半减期之间关系，寻找一种简便有效的半减期推算方法。方法470例Graves’甲亢拟行^131I治疗的患者，按常规测量4、6及24h吸碘率，同时进行有效半减期的检测。按高峰是否前移及前移时间将数据组分为：4h高峰前移组（A组）、6h高峰前移组（B组）及高峰无前移组（C组），所有分组数据行t检验。结果A组22例（4．68％）、B组95例（20．21％）、C组353例（75．11％），各组有效半减期分别为：（4．26±0．79）d、（4．92±0．82）d及（5．89±0．86）d，组间均有显著性差异（p〈0．01）。结论利用摄碘率峰值时间可初步判断有效半减期的长短，指导并调整Graves’甲亢患者服^131I放射性活度。

To predict the effective half-life in Graves' disease by using the peak of iodine-131 uptake rate

Objective To explore the relationship between the peak of iodine - 131 uptake rate and the effective half- life in Graves＇ disease, find a simple method to predict the effective half- life. Methods 470 patients with Graves＇ disease planning to therapy with iodine - 131 were selected. The ratio of 4, 6 and 24h iodine - 131 uptake rate and the effective half- life were performed in all patients. 470 cases were divided into three groups according to the peak of 131/ uptake rate. these data were counted using t test. Results the cases which advanced peak of ^131I uptake in 4h were 22 （ 4. 68 % ）. The cases which advanced peak of ^131I uptake in 6h were 95 （ 20. 21% ）. The cases without advanced peak were 353 （ 75. 11% ）. The effective half- life of the three groups were （ 4. 26 ± 0. 79 ） d（ advanced peak of ^131I uptake in 4h）, （4. 92±0. 82）d（6h） and （5.89±0. 86 ） d （ without advanced peak） respectively. There were significant differences between them （ p 〈 0. 01 ）. Conclusion The peak of iodine - 131 uptake rate could be used to predict the effect half- life preliminary, and guide the radioactivity of iodine in Graves＇ disease.