| 上海市药品不良反应自发呈报数据库中神经系统药物不良反应的信号检测 |
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| 引用本文： | 刘媛,程能能,杜文民,王永铭.上海市药品不良反应自发呈报数据库中神经系统药物不良反应的信号检测[J].中国临床药学杂志,2010(2):85-88. |
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| 作者姓名： | 刘媛 程能能 杜文民 王永铭 |
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| 作者单位： | 复旦大学药学院药理学教研室;上海市药品不良反应监测中心; |
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| 摘 要： | 目的对上海市药品不良反应自发呈报数据库进行神经系统药物不良反应（ADR）信号检测，并研究已知ADR报告对ADR信号检测效率的影响。方法建立ADR信息库以自动判别ADR数据库中已知ADR报告，采用PRR信号检测算法对上海市2004--2007年药品不良反应自发呈报数据库进行信号检测，并计算可解释度以评价检出的信号。结果建立了包含1261种药物，4238种药物-事件组合的神经系统ADR信息库；筛除已知ADR报告后神经系统ADR信号检出率提高了24．64％；经信号检测获得神经系统ADR信号98条，包括卡培他滨-咽下困难、吗替麦考酚酯-视觉异常、头孢他啶-精神病等值得关注的信号。结论筛除已知报告能显著提高神经系统ADR信号的检测效率。
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| 关 键 词： | 自发呈报系统 药品不良反应 信号检测 神经系统疾病 |
Signal detection of nervous system from Shanghai spontaneous ADR reporting system reports |
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| LIU Yuan,CHENG Nengneng,DU Wenmin,WANG Yongming.Signal detection of nervous system from Shanghai spontaneous ADR reporting system reports[J].Chinese Journal of Clinical Pharmacy,2010(2):85-88. |
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| Authors: | LIU Yuan CHENG Nengneng DU Wenmin WANG Yongming |
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| Institution: | 1Department of Pharmacology/a>;School of Pharmacy/a>;Fudan University/a>;Shanghai 200032/a>;China/a>;2Shanghai Center for Adverse Drug Reaction Monitoring/a>;Shanghai 200040/a>;China |
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| Abstract: | AIM To examine the efficiency of adverse drug reaction(ADR) signal detection based on spontaneous reporting system(SRS) database while known ADR reports were excluded partially or totally and to identify potential ADR signals of nervous system.METHODS An ADR database of nervous system was established,which was used to remark known ADR reports from SRS automatically.ADR signals of nervous system were generated for possible hazards from proportional reporting ratios(PRR).A new measure representing the associa... |
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| Keywords: | spontaneous reporting system adverse drug reaction signal detection nervous system disease |
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