TTF-1、CK7、CK5/6、P63和CK20在黏液性肺癌中的表达及意义

目的评价TTF-1、CK7、CK5/6、P63和CK20在黏液性肺癌中的表达特征并探讨其诊断价值。方法 15例黏液性肺癌手术切除标本,其中包括印戒细胞性腺癌（SRCA）5例,肠型腺癌（ITA）4例,黏液性细支气管肺泡癌（m-BAC）3例,伴有黏液的实性腺癌（SA）2例,黏液（胶样）腺癌（MCA）1例;另选取肺腺癌50例（包括非黏液性细支气管肺泡癌13例）,进行免疫组织化学检测。结果黏液性肺癌和肺腺癌TTF-1阳性率分别为60.0%（9/15）和94.0%（47/50）;CK7分别为100%（15/15）和96.0%（48/50）;CK5/6分别为0和2.0%（1/50）;P63分别为13.3%（2/15）和12.0%（6/50）;CK20分别为6.7%（1/15）和0。结论与肺腺癌相比,黏液性肺癌具有较独特的免疫表型,TTF-1阳性率低而CK20可阳性表达;CK7阳性表达有助于证实原发性黏液性肺癌的诊断。

Expression and significance of TTF-1, CK7, CK5/6,P63 and CK20 in mucin producing lung cancer

Objective To evaluate the expression patterns of TTF-1,CK7,CK5/6,P63 and CK20 in mucin producing lung cancer,and investigate the utility of immunohistochemical markers in differential diagnosis.Methods 15 mucin producing carcinoma of lung,including 5 signet ring cell adenocarcinoma,4 intestinal type adenocarcinoma. 3 mucinous bronchioloalveolar carcinoma,2 solid adenocarcinoma with mucin production,and 1 mucinous （colloid） adenocarcinoma,50 conventional lung adenocarcinoma（13 non-mucinous bronchioloalveolar carcinoma） were Studied with a panel of immunoslains.Results TTF-1 were expressed in 60.0%（9/15） of mucin producing carcinoma of lung and 94.0%（47/50） in lung adenocarcinoma;Mucin producing carcinoma of lung and lung adenocarcinoma exhibit a high frequency of CK7 expression with 100%（15/15） and 96.0%（48/50） respectively;CK5/ 6 expression was 0 and 2.0%（1/50） respectively;P63 was 13.3%（2/15） and 12.0%（6/50）;CK20 expression was 6.7%（1/15） and 0,while negative immunohistochemical reactivity was seen in all lung adenocarcinoma.Conclusion Compared with lung adenocarcinoma,mucin producing carcinoma of lung often exhibit lower frequency of TTF- 1 and CK20 positive expression;CK7 positive expression was useful for confirming origin of lung cancer.