白细胞介素-1受体拮抗剂基因型2/2与白塞病葡萄膜炎易感性的相关研究

目的：探讨白细胞介素-1受体拮抗剂（IL-1ra）基因多态性与白塞病（Behcet′s disease，BD）葡萄膜炎间的相关性。方法：应用测定短串联重复序列的PCR技术，对27例BD患者和71例健康对照组IL-1ra基因多态性进行测定。结果：BD患者和对照组之间的IL-1ra等位基因和基因型频率差异无统计学意义（P＞0.05）。基因型2/2能增加BD葡萄膜炎易感性(OR=3.3)。其他IL-1ra基因型或基因频率与BD葡萄膜炎无关。结论：IL-1ra基因型2/2与增加BD葡萄膜炎易感性有关。

Association of IL-1 receptor antagonist gene 2/2 genotype with increased susceptibility for Behcet's disease with uveitis

Objective: To investigate a possible association of specific polymorphisms of interleukin 1(IL-1) receptor antagonist (IL-1ra) genes with susceptibility for Behcet′s disease (BD) with uveitis. Methods: The genotypes of a total of 27 BD patients and 71 controls were determined for IL-1ra variable number of tandem repeat polymorphisms (for five different alleles) by PCR. χ²-analysis was used to compare the allele and genotype frequencies of patients and controls. Results: There was no difference in the allele or genotype frequencies of IL-1ra between patients with BD and the controls (P＞0.05). The 2/2 genotype of IL-1ra polymorphisms was identified as an increased risk of BD with uveitis(OR=3.3).No association was produced for other investigated polymorphisms in the genotype or allele frequencies of IL-1ra between the BD patients or BD patients with uveitis and the control. Conclusion： Susceptibility to BD with uveitis is enhanced in individuals carrying the 2/2 genotype of IL-1ra polymorphisms.