| 急性低气压性缺氧对小鼠心电活动的影响 |
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| 引用本文： | 吴伟康,易慧智,罗汉川,尧宏斌,侯灿. 急性低气压性缺氧对小鼠心电活动的影响[J]. 高原医学杂志, 1994, 0(3) |
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| 作者姓名： | 吴伟康 易慧智 罗汉川 尧宏斌 侯灿 |
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| 作者单位： | 中山医科大学病理生理学教研室 |
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| 摘 要： | 本文研究了低气压环境下小鼠心电活动的特点，并以心电活动时间（ＣＥＡＴ）为指标，观察了不同气压、增龄、药物对小鼠心电活动的影响。结果发现：随气压下降，ＣＥＡＴ缩短；随增龄，ＣＥＡＴ缩短；冬眠灵、三磷酸腺鲁可延长ＣＥＡＴ，而肾上腺素则显著缩短ＣＥＡＴ。上述结果提示：缺Ｏ＿２越严重，ＣＥＡＴ越短；老化可削弱心脏对缺Ｏ＿２的耐受力，降低氧耗或／和增加能量供应，可增强心脏对缺Ｏ＿２的耐受，反之则损害心肌的电活动。同时，还提示用ＣＥＡＴ来反映小鼠心脏对缺Ｏ＿２的耐受性，具有客观、定量、准确、灵敏的特点。
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| 关 键 词： | 低气压，缺氧，小鼠，心脏，心电图 |
EFFECTS OF ACUTE LOW AIR-PRESSURE ON CARDIOELECTRIC ACTIVITY OF MICE |
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| Wu Weikang,et al. EFFECTS OF ACUTE LOW AIR-PRESSURE ON CARDIOELECTRIC ACTIVITY OF MICE[J]. Journal of High Altitude Medicine, 1994, 0(3) |
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| Authors: | Wu Weikang et al |
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| Affiliation: | Wu Weikang,et al Department of Pathophysiology,Sun Yat-Sen University of Medical |
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| Abstract: | he characters of cardioelectric activity of mice under air-pressure were studied,and the ef- fects of various air-pressure environments,aging and drugs on cardioelectric activity of micewere observed by measuring cardioelectric activity time(CEAT). The results indicate that with the decline of air-pressure,CEAT became shortened;withaging,CEAT became shortened too;reducing oxygen consumption or/and increasing supply ofenergy could strengthen the tolerance to hypoxia;conversely,cardioelectric activity will be dis- turbed,and that utilizing CEAT to measure ability of heart to resist hypoxia has the characters ofobjectivity,quantitation and accuracy. |
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| Keywords: | low air-pressure hypoxia mice heart electrocardiogram |
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