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| 痴呆大鼠模型的行为学、脑内胆碱乙酰转移酶及突触素改变 | |
| 引用本文： | 王哲,张昱,李华军,田沈. 痴呆大鼠模型的行为学、脑内胆碱乙酰转移酶及突触素改变[J]. 神经疾病与精神卫生, 2003, 3(4): 253-255 |
| 作者姓名： | 王哲 张昱 李华军 田沈 |
| 作者单位： | 1. 130021,吉林大学第一医院神经内科 2. 北京空军总医院 3. 沈阳铁路局总医院 |
| 摘 要： | 目的：观察Meynert核损害对大鼠脑内胆碱乙酰转移酶(ChAT)和突触素(P38)的影响。方法：Ibotenic acid定位损伤大鼠脑建立AD模型，利用水迷宫和跳台观察其行为学改变，利用原位杂交、免疫组化及图像分析测定大鼠脑内胆碱乙酰转移酶(ChAT)和突触素的表达。结果：胆碱能损害组大鼠的学习记忆能力低于正常对照组和假手术组，其脑内ChAT和突触素的表达也明显下降。结论：保护中枢胆碱能系统和增加突触素水平有助于改善认知记忆能力。 |
| 关 键 词： | 痴呆 大鼠模型 行为学 脑 胆碱乙酰转移酶 突触素 |
| 文章编号： | 1009-6574(2003)04-0253-03 |
| 修稿时间： | 2002-11-20 |
Changes of Praxiology, Choline Acetyltransferase and Synapase in AD Model Rats with Nucleus Basalis-lesioned |
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| Wang Zhe,Zhang Yu,Li Huajun,et al.. Changes of Praxiology, Choline Acetyltransferase and Synapase in AD Model Rats with Nucleus Basalis-lesioned[J]. Nervous Diseases and Mental Health, 2003, 3(4): 253-255 | |
| Authors: | Wang Zhe Zhang Yu Li Huajun et al. |
| Abstract: | Objective To observe the changes of choline acetyltransferase (ChAT) and synapse in rats brain with basal nuclei lesion. Methods The Ibotenic acid was injected into the bilateral nucleus basalis of Wistar rats to make the model of Alzheimer disease. The changes of learning and memory, the contents of choline actyltransferase(ChAT) and synapse in brain were studied. Results Comparing with other groups, significant decrease was shown in the ability of learning and memory, the contents of choline actyltransferase (ChAT) and synapse in the groups with the lesion of bilateral nucleus basalis (P < 0.01). Conclusions Protecting central cholinergic system and elevating the level of synapse could improve the ability of learning and memory. |
| Keywords: | Alzheimer's disease Model Choline actyltransferase Synapse |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |