Correlation analysis of celiac sprue tissue transglutaminase and deamidated gliadin IgG/IgA

AIM:To indirectly determine if tissue transglutaminase (tTG)-specific T cells play a crucial role in the propagation of celiac disease.CONCLUSION: These data demonstrate that the production of anti-tTG IgA is directly correlated to the production of anti-DGP IgG and IgA, whereas antitTG IgG is only weakly correlated. This result therefore supports the hapten-carrier theory that in wellestablished celiac patients anti-tTG IgA is produced by a set of B cells that are reacting against the complex of tTG-DGP in the absence of a tTG-specific T cell.