高频震荡通气治疗新生儿肺透明膜病

目的：评价高频振荡通气治疗新生儿肺透明膜病的疗效。方法：将32例新生儿呼吸窘迫综合征患儿分成两组，16例采用高频振荡通气治疗，16例常规机械通气治疗；观察两组患儿的肺功能及并发症。结果：高频振荡通气组患儿在治疗后6，12，24h，氧浓度、氧合指数明显下降并低于机械通气组，动脉／肺泡氧分压比值明显上升并高于机械通气组，有显著性差异（P〈0．05或0．01）。高频振荡通气组并发症和病死率低于机械通气组，存活的患儿的上机时间、氧疗时间、住院时间比机械通气组短，差异有显著性（P〈0．05或0．01）。结论：高频振荡通气能更好改善肺透明膜病患儿的肺氧合功能，减少并发症，缩短病程，降低病死率，对治疗具有很好的疗效。

High-frequency oscillatory ventilation for neonatal hyaline membraue disease

Objective To study the effect of high-frequency oscillatory ventilation to newborn infants with neonatal hyaline membrane disease.WTHZ]Methods Thirty-two infants with neonatal hyaline membrane disease were divided into 2 groups,16 cases treated with high-frequency oscillatory ventilation and 16 cases treated with conventional mechanical ventilation. Results The mean fractional inspired oxygen and oxygenation index were decreased,and arterial/alveolar PO_2 was increased after treatment with high-frequency oscillatory ventilation from 6 to 24 hours in high-frequency oscillatory ventilation group,which was significantly different compared with the conventional mechanical ventilation((P<0.05,P<0.01)).The time of mechanical ventilation and hospitalization was shorter in high-frequency oscillatory ventilation group((P<0.05)),and complications and mortality rate were low((P<0.01)).Conclusion High-frequency oscillatory ventilation therapy may result in a rapid improvement in oxygenation,and shorten the duration of mechanical ventilation hospitalization time,reduce the complication and mortality rate in newborn infants with neonatal hyaline membrane disease.