Peripheral neuropathy in patients on leflunomide |
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| Authors: | Bharadwaj A Haroon Nigil |
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| Affiliation: | Department of Immunology–Rheumatology, Kasturba Medical College, Manipal, India |
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| Abstract: | SIR, Much progress has been made in understanding the pathogenesisof rheumatoid arthritis. This has resulted in the developmentof novel therapeutic strategies. Leflunomide is a disease-modifyinganti-rheumatic drug (DMARD) which is in vogue all over the world.The active metabolite of leflunomide, A77 1726, reversibly inhibitsdihydroorotate dehydrogenase (DHODH), the rate-limiting stepin the de novo synthesis of pyrimidines [1]. The side-effects |
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