试论现代中药衍生的“有效部位配伍”新药模式

作为现代中药开发的新模式——“有效部位配伍”的研究思路已由传统发掘中药（复方）有效部位转化为开发以中医药理论或现代医药理论指导下的中药微观复方。同时其研究目标和方法也得到更新，具体包括治疗疾病目标化、配伍比例优选化、组分类型标准化、协同与拮抗明确化、毒性和副作用最小化。根据目前“有效部位配伍”模式研究的现状提出了需完善之处，旨在探究有效部位配伍组方的新药模式，丰富中医药理论内涵，推动中医药现代化发展进程。

Combination of Effective Components, the New Pattern of Drugs Derived from Modern Chinese Herbal Medicine

The thinking of research on developing Chinese herbal medicine (CHM) has turned from the traditional exploration for active ingredients to develop microcosmic compound drug based on TCM and/or modern medical theories, which leads to the emerge of combination of effective components (CEC), a new pattern of developing modern Chinese herbal medicine. Meanwhile its researching targets and methods, including objectivization of treated diseases, optimization of compatibility proportion, standardization of component types, definition of synergistic and antagonistic effects, and minimization of toxic and side effects, have also been renewed. The existent problems in need of improvement were put forward on the basis of current researching situation of CEC pattern in order to construct new drugs, enrich the theoretical connotation of TCM and promote the process of TCM modernization.