高血压患者颈动脉病变与血管活性物质相关性探讨

为探讨高血压患者颈动脉病变与血管活性物质的关系，对105例高血压患者行颈动脉超声检查，根据病变的不同情况分为正常组（30例），增厚组（30例），硬斑块组（30例）和软斑块组（15例），对上述患者测定血清中一氧化氮，内皮素，神经肽－Y，低密度脂蛋白及纤维蛋白原水平，结果发现，颈动脉软斑块组与正常组比较，神经肽－Y，低密度脂蛋白和纤维蛋白原生成增加，一氧化氮生成减少（P＜0．05），颈动脉硬斑块组与正常组比较上述指标也有差异（P＜0．05），提示颈动脉斑块的形成与高血压引起的内皮损伤，脂质代谢异常有明显关系。

Association of Carotid Lesions with Vasoactivators in Hypertensive Patients

Aim To access the relationship between carotid lesions and some vasoactivators in patients with hypertension. Methods 105 hypertensive patients were divided into four groups based on the result of carotid arterial sonography: normal group(30 cases), endothelial thickness group(30 cases), hard plaque group(30 cases) and soft plaque group(15 cases). Several vasoactivators were determined in these patients, including nitrogen monoxide(NO), endothelin(ET), neuropeptide Y(NPY), fibrinogen(FIB), low density lipoprotein(LDL) and total cholesterol(TC). Results Compared with non-plaque group,soft plaque group had higher levels of LDLC,NPY, FIB and lower levels of NO. The difference was significant(P<0.05). Hard plaque group had also different levels of above vasoactivor parameters from that of normal group (P<0.05). Conclusion There was a significant association between the formation of carotid atherosclerotic lesions and the hypertensive injury and disorders of lipids metabolism.