慢性三氯化镧暴露对大鼠血糖和血脂水平的影响

目的探讨稀土元素镧的慢性暴露对大鼠血糖、血脂的影响。方法分别以0.1、2和40 mg/kg剂量的三氯化镧(LaC l3)给大鼠经口灌胃,每天1次,90 d后处死;取全血测定糖化血红蛋白(HbA1 c),分离血清测定血糖(G lu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果与对照组相比,3个LaC l3暴露剂量组大鼠HbA1C、血清G lu、TG和LDL-C水平无统计学意义;0.1和2 mg/kg剂量LaC l3暴露组大鼠血清TC水平分别为(1.38±0.14)mmol/L和(1.37±0.26)mmol/L,与对照组大鼠(1.57±0.14)mmol/L相比有明显降低;0.1 mg/kg剂量LaC l3暴露组大鼠血清HDL-C为(0.79±0.12)mmol/L,比对照组大鼠(0.93±0.10)mmol/L有明显降低。结论0.1~40 mg/kg LaC l3慢性暴露对大鼠血清G lu、TG和LDL-C水平无显著影响;低、中剂量LaC l3慢性暴露可使大鼠血清TC和HDL-C降低。

Effects on serum glucose and lipids in chronic exposure to lanthanum chloride in rat

OBJECTIVE: To explore the effects of serum glucose and lipids by on chronically lanthanum exposure in rat. METHODS: The Wistar rats were treated with oral exposure dose 0.1, 2 and 40 mg/kg of lanthanum chloride (LaCl(3)) respectively, after 90 days the rats were sacrificed and the blood was collected for measuring the glycosylated hemoglobin A (HbA1c), the serum was used for measuring glucose, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) levels. RESULTS: There were no any differences among the control and 3 dose LaCl(3) exposed rats on the blood HbA1c and serum Glu, TG and LDL-C levels (P > 0.05). The serum TC in 0.1 and 2 mg/kg LaCl(3) dose group rats were (1.38 +/- 0.14) mmol/L and (1.37 +/- 0.26) mmol/L respectively. It was lower than that of the controls (1.57 +/- 0.14) mmol/L significantly (P < 0.05), the serum HDL-C in 0.1 mg/kg dose group rats was (0.79 +/- 0.12) mmol/L and obviously lower than that of control group rats (0.93 +/- 0.10) mmol/L (P < 0.05). CONCLUSION: 0.1 - 40 mg/kg LaCl(3) chronically exposed have not greater effect on serum glucose, TG and LDL-C levels in rats, but the lower dose LaCl(3) chronic exposure might cause serum TC and HLD-C level decreasing.