| ~(99)Tc~m-HL91 SPECT乏氧显像在非小细胞 |
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| 引用本文： | 丁小博,金刚,王艳波,赵颖,王迎秋,刘玉婷. ~(99)Tc~m-HL91 SPECT乏氧显像在非小细胞[J]. 肿瘤防治研究, 2010, 37(2) |
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| 作者姓名： | 丁小博 金刚 王艳波 赵颖 王迎秋 刘玉婷 |
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| 作者单位： | 丁小博,DING Xiao-bo(吉林大学第一医院放射科);金刚,刘玉婷,JIN Gang,LIU Yu-ting(哈尔滨医科大学附属第二医院核医学科,150086);王艳波,WANG Yan-bo(吉林大学第一医院外科);赵颖,王迎秋,ZHAO Ying,WANG Ying-qiu(齐齐哈尔市第一医院医学科) |
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| 摘 要： | 目的 探讨~(99)Tc~m-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)乏氧显像对非小细胞肺癌放疗近期疗效的评价. 方法 31例拟接受三维适形放射治疗的非小细胞肺癌患者,在放疗前2天、后2天分别静脉注射~(99)Tc~m-HL91 740-925MBq后进行4 h及24 h SPECT断层显像,根据显像进行目测和半定量分析(T/N值,靶与非靶比值),根据放疗前24h显像T/N值将患者分为低摄取组(T/N<2.76,n=6)及高摄取组(T/N≥2.76,n=25),对两组放疗近期疗效进行比较. 结果 低摄取组放疗近期有效率为83.3%(1/6)高于高摄取组为44.0%(11/25),两组比较差异有统计学意义(P<0.05).两组24 h断层显像T/N比值下降率分别为30.3%和13.3%,两组比较差异有统计学意义(P<0.05). 结论 ~(99)Tc~m-HL91非小细胞肺癌乏氧显像在预测放疗近期效果方面具有一定的临床价值.
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| 关 键 词： | 肺肿瘤 放射疗法 细胞低氧 放射性核素显像 |
Clinical Application of ~(99)Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer |
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| DING Xiao-bo,JIN Gang,WANG Yan-bo,ZHAO Ying,WANG Ying-qiu,LIU Yu-ting. Clinical Application of ~(99)Tcm-HL91 Hypoxia Imaging in Radiotherapy of Patients with Non-small Cell Lung Cancer[J]. Cancer Research on Prevention and Treatment, 2010, 37(2) |
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| Authors: | DING Xiao-bo JIN Gang WANG Yan-bo ZHAO Ying WANG Ying-qiu LIU Yu-ting |
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| Affiliation: | DING Xiao-bo1,JIN Gang1,WANG Yan-bo2,ZHAO Ying3,WANG Ying-qiu3,LIU Yu-ting11.Department of Nuclear Medicine,The Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China,2.Department of Surgery,The First Hospital of Jilin University,3.Department of Nuclear Medicine,The First Hospital of Qiqihar City(*Present:Department of Radiology,First Hospital of Ji'nin University) |
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| Abstract: | Objective To detect hypoxia status of non-small cell lung cancer with serial 99Tcm -4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (HL91) SPECT images and predict the short-time curative effect about radiotherapy in lung cancer.Methods Thirty-one patients with non-small cell lung cancer underwent SPECT imaging at 4h and 24h after injecting 99Tcm-HL91,respectively.Regions of interest(R0Is)were drawn in the tumor(T)and contralateral position(N)and the radioactivity ratios of tumor to normal(T/N)wer... |
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| Keywords: | Lung neoplasm Radiotherapy Hypoxia Radionuclide imaging |
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