Phencyclidine decreases methionine-enkephalin content in rat striatum |
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| Authors: | W Fratta B Zivcovic G L Gessa |
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| Institution: | 1. Institute of Pharmacology, University of Cagliari, Via Porcell 4, 09100 Cagliari Italy;2. Synthelabo, LERS, Bagneux France |
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| Abstract: | The acute administration of phencyclidine induced a decrease in methionine-enkephalin levels in rat striatum, as measured by specific radioimmunoassay. The maximum decrease (about 40% with respect to controls) was obtained at a dose of 20 mg/kg, 30 min after intraperitoneal injection. These results suggest a possible involvement of enkephalins in the central effects of phencyclidine. |
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| Keywords: | phencyclidine methionine-enkephalin striatum hypothalamus rat |
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