Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice |
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Authors: | Koike Hiroko Arguello P Alexander Kvajo Mirna Karayiorgou Maria Gogos Joseph A |
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Institution: | Human Neurogenetics Laboratory, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. |
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Abstract: | Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence between 129S6/SvEv and C57BL/6J mouse strains and have implications for modeling psychiatric diseases in mice. |
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