| 广西壮族人HLA-DQB1等位基因与β地中海贫血的相关性 |
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| 引用本文： | 龙桂芳,阿卜迪.广西壮族人HLA-DQB1等位基因与β地中海贫血的相关性[J].中华血液学杂志,1998,19(10):528-530. |
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| 作者姓名： | 龙桂芳 阿卜迪 |
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| 作者单位： | 广西医科大学第一附属医院 |
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| 摘 要： | 目的：探讨ＨＬＡ抗原与β地中海贫血（地贫）的相关性。方法：应用聚合酶链反应序列特异引物（ＰＣＲＳＳＰ）方法对６４名随机抽样的，无血缘关系，三代以上均为壮族并三代以上居住在广西，籍贯分布广西各地，均在本实验室经基因诊断证实为β地贫的患者进行ＨＬＡＤＱＢ１基因分型。结果：发现ＨＬＡＤＱＢ１０６０４等位基因在该群体中频率为１２．５％，对照组为１．４％；其相对危险度为９．９，与对照组比较，有非常显著差异（显著性检验χ２＝２０．７８，Ｐ＜０．００５）。结论：提示ＨＬＡＤＱＢ１０６０４等位基因与广西壮族居民β地贫的易感性有关联
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| 关 键 词： | β地中海贫血 HLA-DQ抗原 聚合酶链反应 壮族 |
Association of HLA-DQB1 alleles and the susceptibility to beta-thalassemia in Guangxi Chinese Zhuang nationality] |
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| Long Guifang,A Abdi Mohamed.First Affiliated Hospital of Guangxi Medical University,Nanning.Association of HLA-DQB1 alleles and the susceptibility to beta-thalassemia in Guangxi Chinese Zhuang nationality][J].Chinese Journal of Hematology,1998,19(10):528-530. |
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| Authors: | Long Guifang A Abdi MohamedFirst Affiliated Hospital of Guangxi Medical University Nanning |
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| Institution: | First Affiliated Hospital of Guangxi Medical University, Nanning 530021. |
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| Abstract: | OBJECTIVE: To investigate the relationship between HLA-DQB1 allele and susceptibility to beta-thalassemia in Guangxi Chinese Zhuang nationality. METHODS: The polymorphism of the HLA-DQB1 loci in 64 randomly selected, unrelated Guangxi Zhuang individuals with beta-thalassemia was investigated by PCR-SSP. RESULTS: Compared with normal controls, the frequency of HLA-DQB1*0604 allele was significantly increased in the patient group, with a relative risk(RR) of 9.9(chi 2 = 20.78, P < 0.005), while the frequencies of other HLA-DQB1 alleles did not in the patient group. CONCLUSION: The susceptibility to beta-thalassemia in the Guangxi Zhuang individuals is associated with HLA-DQB1*0604 allele. |
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