| 国内12年间苯妥英钠不良反应文献分析 |
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| 引用本文： | 朱曼,郭代红,孙艳,张莉. 国内12年间苯妥英钠不良反应文献分析[J]. 中国药业, 2007, 16(19): 38-39 |
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| 作者姓名： | 朱曼 郭代红 孙艳 张莉 |
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| 作者单位： | 中国人民解放军总医院药品保障中心第一临床药局,北京,100853 |
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| 摘 要： | 目的了解苯妥英钠不良反应(ADR)发生的一般规律及特点。方法收集国内12年间关于苯妥英钠ADR的文献源并加以统计分析。结果苯妥英钠ADR的发生男性多于女性,且集中于10～40岁年龄段,以中枢神经系统(CNS)、血液系统和皮肤的损害为主,预后较好,有95.77%的患者痊愈或好转,4.23%的患者死亡。结论临床治疗中应重视苯妥英钠所致ADR,加强血药浓度监测,确保用药的合理性和安全性。
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| 关 键 词： | 苯妥英钠 不良反应 文献分析 |
| 文章编号： | 1006-4931（2007）19-0038-02 |
| 修稿时间： | 2007-03-28 |
Analysis of Adverse Drug Reaction of Phenytion Sodium Reported in Domestic Medical Journals within Past 12 Years |
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| Zhu Man,Gao Daihong,Sun Yan,Zhang Li. Analysis of Adverse Drug Reaction of Phenytion Sodium Reported in Domestic Medical Journals within Past 12 Years[J]. China Pharmaceuticals, 2007, 16(19): 38-39 |
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| Authors: | Zhu Man Gao Daihong Sun Yan Zhang Li |
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| Affiliation: | The First Clinical Pharmacy, Drug Guarantee Center, Chinese PLA General Hospital, Beijing, China 100853 |
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| Abstract: | Objective To investigate the rules and characteristics of adverse drug reactions (ADR) of phenytion sodium.Methods The data of ADR of phenytion sodium on literatures within 12 years were analyed.Results The patients aged from 10 to 40 and male were more than female.Nervous system was the most frequent,the following were blood system and skin injury.The outcome of ADR was well,95.77%of the patients could cure or improve.But also 4.23%of the patients were dead.Conclusion Great attention should be paid to the ADR of phenytion sodium in clinic and the clinical monitoring should be enhanced.Be sure safe and rational in clinical phenytion sodium application. |
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| Keywords: | phenytion sodium adverse drug reaction literature analysis |
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