| 严重创伤患者白细胞介素—2及其受体变化与多器官功能障碍综合 … |
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| 引用本文： | He Z,Wang S,Su Z,Huang Y,Yang J. 严重创伤患者白细胞介素—2及其受体变化与多器官功能障碍综合 …[J]. 中华外科杂志, 1999, 37(8): 492-493 |
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| 作者姓名： | He Z Wang S Su Z Huang Y Yang J |
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| 摘 要： | 目的 探讨血清白介素－２（ＩＬ－２）与可溶性白介素－２受体（ｓＩＬ－２Ｒ）在创伤后多器官功能障碍综合征（ＭＯＤＳ）发生、发展中的作用机制。方法 应用ＥＬＩＳＡ法动态监测５９例严重创伤患者血清ＩＬ－２与ｓＩＬ－２Ｒ水平变化,比较ＭＯＤＳ与非ＭＯＤＳ组间ＩＬ－２、ｓＩＬ－２Ｒ变化之差异。结果 ５９例患者血甭ｓＩＬ－２Ｒ水平显著升颃是ＩＬ－２明显下降,且升 峰值与降低之谷值在ＭＯＤＳ组更为明显,与非ＭＯ
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| 关 键 词： | 创伤 多器官衰竭 白细胞介素2 受体 |
Changes of interleukin-2 and soluble interleukin-2 receptor serum level and multiple organ dysfunction syndrome in severely traumatic patients |
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| He Z,Wang S,Su Z,Huang Y,Yang J. Changes of interleukin-2 and soluble interleukin-2 receptor serum level and multiple organ dysfunction syndrome in severely traumatic patients[J]. Chinese Journal of Surgery, 1999, 37(8): 492-493 |
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| Authors: | He Z Wang S Su Z Huang Y Yang J |
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| Affiliation: | Hainan Provincial People's Hospital, Haikou 570311. |
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| Abstract: | OBJECTIVE: To evaluate the role in the changes of interleukin-2 (IL-2) and soluble interleukin-2R (sIL-2R) serum level in the mechanism of post-traumatic multiple organ dysfunction syndrome (MODS). METHODS: 59 severe traumatic patients were divided into MODS group (n = 24) and non-MODS group (n = 35) according to the occurrence of MODS after trauma. The changes in IL-2 and sIL-2R serum level were observed by enzyme linked immunoabsorbed assay (ELISA). Sera from 30 healthy individuals were used as normal controls. RESULTS: The serum level of sIL-2R was increased and that of IL-2 decreased in 59 traumatic patients. These changes were more marked in the MODS group than in non-MODS group (p < 0.05). CONCLUSIONS: The changes in IL-2 and sIL-2R serum level after trauma might participate in the mechanism of post-traumatic MODS. |
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