甲巯咪唑治疗妊娠合并甲状腺功能亢进孕妇时对新生儿甲状腺功能影响

目的探讨甲巯咪唑（MMI）治疗妊娠合并甲状腺功能亢进患者时，药物剂量对新生儿甲状腺功能的影响。方法对30例妊娠合并甲状腺功能亢进接受不同剂量MMI治疗的孕妇（治疗组），分娩时测定新生儿脐血的TT3、TT4、FT3，FT4及TSH值，并以同期30例正常孕妇的新生儿脐带血作为对照组，进行比较分析。结果治疗组的新生儿TT3、TT、FT3、FT4及TSH与正常对照组相比，差异均无统计学意义（P〉0．05）。MMI剂量在每天5～15mg内与脐血TT3、TT、FT3，FT4水平无关，与TSH水平呈正相关。结论适量的MMI治疗妊娠合并甲状腺功能亢进是相对安全的，可改善母婴的妊娠结局，预防新生儿甲状腺功能亢进而不会造成新生儿甲状腺功能减退。

Effect of methimazole on fetal thyroid function in mother with hyperthyroidism

Objective To investigate the thyroid function in the treatment of hyperthyroidism in pregnancy with different dose of methimazole（MMI）. Methode 30 patients with newly diagnosed hyperthyroidism in pregnancy as treatment group was received different dose MMI, the levels of TT3 ,TT,FT3 ,FT4 and TSH in 30 cases of hyperthyroid gravida as control group was measured in delicery in cord serum samples. Results There was no significanct difference in baseline thyroid function parameters between the two groups, little relationship was observed between matemal doses and fetal thyroid function （TT3 , TT4 ,FT3, FT4 ） （P 〉 0.05 ） ;When low doses of M MI （5 - 15mg daily or less）were adminiostered. Lower doses were associated normal or low fetal TSH levels. Conclusion The propriety methimazole can be used in pregnancy,which is safe,cheap and improve the pregnancy outcomes,prevent infant＇s hyperthyroidism or hypothyroidism.